Increased serum carnitine concentration in renal insufficiency.

نویسندگان

  • S H Chen
  • S D Lincoln
چکیده

We measured serum carnitine in groups of patients with various diseases. The concentration was frequently above normal in patients with renal insufficiency. The clinical significance of such an increase in renal insufficiency may be analogous to that of increases in urea nitrogen, creatinine, or uric acid in the serum.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Renal insufficiency after infrarenal abdominal aortic aneurysm reconstruction: An analysis of this risk factor in 45 patients

 Abstract Background: Renal insufficiency is a potential complication after infrarenal abdominal aortic aneurysm repair and is a significant risk factor for postoperative mortality and morbidity. The aim of this study was to analyze the effect of this risk factor, before and during operation. Methods: In this prospective study, between 2003 and 2006, 45 patients underwent repair of an infrarena...

متن کامل

اثرات مکمل L- کارنیتین بر روی سیتوکین‌های التهابی، CRP و استرس اکسیداتیو در بیماران همودیالیزی

Background: Inflammation and oxidative stress are common in patients with chronic renal disease, including hemodialysis patients. The present study was designed to investigate the effects of L-carnitine supplements on inflammatory cytokines, CRP and oxidative stress in hemodialysis patients. Materials and methods: The study was a randomized clinical trial. Thirty-six hemodialysis patients, (2...

متن کامل

Pharmacokinetic analysis of the cardioprotective effect of 3-(2,2, 2-trimethylhydrazinium) propionate in mice: inhibition of carnitine transport in kidney.

The site of action of 3-(2,2,2-trimethylhydrazinium) propionate (THP), a new cardioprotective agent, was investigated in mice and rats. I.p. administration of THP decreased the concentrations of free carnitine and long-chain acylcarnitine in heart tissue. In isolated myocytes, THP inhibited free carnitine transport with a Ki of 1340 microM, which is considerably higher than the observed serum c...

متن کامل

Differential effects of oral and intravenous l-carnitine on serum lipids: is the microbiota the answer?

L‐carnitine (free carnitine) transports cytosolic long‐chain fatty acids as acylcarnitines across the inner mitochondrial membrane for β‐oxidation and subsequent ATP production in the mitochondria. The endogenous carnitine pool comprises free L-carnitine as well as short-, mediumand long-chain fatty acid esters (acyl-carnitines) and depends on absorption of L-carnitine from dietary sources, end...

متن کامل

Myocardial function, energy provision, and carnitine deficiency in experimental uremia.

Cardiac complications are the leading cause of mortality in patients with chronic renal failure. Secondary carnitine deficiency, which is frequently observed in hemodialysis patients, has been associated with cardiac hypertrophy and heart failure and may impair myocardial fatty acid oxidation. In chronic kidney disease, impaired carnitine homeostasis also may affect myocardial metabolism. In th...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Clinical chemistry

دوره 23 2 PT. 1  شماره 

صفحات  -

تاریخ انتشار 1977